Overview:

Newly developed microscopy techniques are providing an unprecedented look at
the biochemical processes that underpin life. These range from cryo electron
microscopy, which reveals structures at the scale of individual
macromolecules, to confocal fluorescence microscopy, which can measure
concentrations of a particular protein at a neural synapse or across an entire
developing animal. Just as microarrays allowed the move from individual genes
to studying the entire genome in parallel, quantitative imaging opens a whole
new spatial dimension of gene expression. Just as microarrays have driven the
development of an entire sub-field of computational biology,
successfully harvesting biological insights from the increasing flood of
imaging data will require a whole new computational and statistical toolbox for
dealing with the spatial aspects of gene expression.
Publications:
Weber, G. H.; Rubel, O.; Huang, M-Y; DePace, A. H.; Fowlkes, C. C.; Keranen, S. V. E.; Hendriks, C. L. Luengo; Hagen, H.; Knowles, D. W.; Malik, J.; Biggin, M. D.; Hamann, B.
IEEE Transactions on Computational Biology and Bioinformatics,
Fowlkes, Charless C.; Malik, Jitendra
UC Berkeley, 2006, UCB//EECS-06-142,
Luengo-Hendriks, C.; Keränen, S.; Fowlkes, C.; Simirenko, L.; Weber, G.; Henriquez, C.; Kaszuba, D.; Hamann, B.; Eisen, M.; Malik, J.; Sudar, D.; Knowles, M. Biggin D.
Genome Biology, 2006, 7:R123,
Keränen, S.; Fowlkes, C.; Hendriks, C. Luengo; Sudar, D.; Knowles, D.; Malik, J.; Biggin, M.
Genome Biology, 2006, 7:R124,
Rubel, O.; Weber, G.H.; Keranen, S.V.E.; Fowlkes, C.C.; Hendriks, C.L. Luengo; Simirenko, L.; Shah, N.Y.; Eisen, M.B.; Biggin, M.D.; Hagen, H.; Sudar, D.; Malik, J.; Knowles, D.W.; Hamann, B.
2006, p. 203--210
Fowlkes, C.; Hendriks, C. Luengo; Keränen, S.; Biggin, M.; Knowles, D.; Sudar, D.; Malik., J.
Csb 2005 workshop on bioimage data minning and informatics, 2005,
Fowlkes, C.; Shan, Q.; Belongie, S.; Malik., J.
Methods of microarray data analysis ii, 2002,