Julian Yarkony, Chong Zhang, Charless Fowlkes
Energy Minimization Methods in Computer Vision and Pattern Recognition, 2015, 492--504.
Newly developed microscopy techniques are providing an unprecedented look at the biochemical processes that underpin life. These range from cryo electron microscopy, which reveals structures at the scale of individual macromolecules, to confocal fluorescence microscopy, which can measure concentrations of a particular protein at a neural synapse or across an entire developing animal. Just as microarrays allowed the move from individual genes to studying the entire genome in parallel, quantitative imaging opens a whole new spatial dimension of gene expression. Successfully harvesting biological insights from the increasing flood of imaging data will require a whole new computational and statistical toolbox for dealing with the spatial aspects of morphology and gene expression.